Paper 2 June 2025 Higher tier, Question 8 17 marks
Also involves Enzyme action · Protein synthesis · Gene mutations
Some people keep rabbits as pets.
Figure 8 shows two types of rabbit.
The Himalayan fur pattern is controlled by a dominant allele.
A heterozygous male Himalayan rabbit was crossed many times with each of two female Himalayan rabbits, A and B.
The results of the two types of cross were different.
• Crosses with female A: all of the 210 offspring were Himalayan rabbits.
• Crosses with female B: some of the 240 offspring were Himalayan rabbits and some were white rabbits.
In Questions 08.1 and 08.2, use the following symbols to represent alleles: H = dominant allele for Himalayan fur h = recessive allele for white fur.
What is the genotype of female Himalayan rabbit A ?
Give the reason for your answer.
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Determine the probability that one of the offspring from a cross with female Himalayan rabbit B will be white.
You should:
• draw a Punnett square diagram
• use the symbols H and h
• identify the phenotype of each offspring genotype.
Probability of offspring being white =
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Adult Himalayan rabbits have:
• white fur over most of the body
• black fur on the nose, ears and feet.
The black colour is caused by production of a substance called melanin.
Figure 9 shows how melanin is made from another substance called tyrosine.
Figure 9
White rabbits have one base change in the gene that codes for the enzyme tyrosinase.
Explain how a change of one base in the DNA of the gene coding for tyrosinase could stop the tyrosinase working.
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For the first four weeks of life, Himalayan rabbits produce white fur over the whole body.
The black areas of fur start to develop after four weeks.
In the first four weeks, young rabbits stay in the nest with their mother.
A rabbit’s body temperature is 39 °C.
The tyrosinase in Himalayan rabbits is:
• most active between 15 °C and 25 °C
• not active above 35 °C.
The fur on the nose, ears and feet of Himalayan rabbits is white for the first four weeks of life.
Explain what causes the fur to be white in the first four weeks of life.
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From the age of four weeks, young rabbits move from the nest to the outside environment.
Explain why a Himalayan rabbit develops black nose, ears and feet from the age of four weeks.
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Melanin is also produced in human skin.
Melanin absorbs ultraviolet (UV) radiation from sunlight and prevents the radiation reaching deep into the skin.
UV radiation is a type of ionising radiation.
Explain the advantage of producing melanin in human skin when exposed to bright sunlight.
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