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AQA GCSE Combined Science: Synergy

Topic questions Human physiology Digestion

Digestion

11 questions · 149 marks · about 2.5 hours

Digestion questions

AQA 8465 Digestion 11 questions

Paper 1: Life and environmental sciences June 2025 Foundation tier, Question 5 10 marks

The endocrine system produces hormones.

5.1

The pituitary gland is part of the endocrine system.

Where is the pituitary gland?

Tick (✓) one box.

In the head

In the heart

In the liver

[1]
Reveal mark scheme Mark scheme for question 5.1
5.2

Oestrogen is a hormone.

Which organ in the female reproductive system produces oestrogen?

Tick (✓) one box.

Kidney

Ovary

Stomach

[1]
Reveal mark scheme Mark scheme for question 5.2
5.3

Some chemicals in the environment affect the body in a similar way to hormones.

A scientist investigated the effect of feeding chemical X to rats.

Table 1 shows the results.

Figure for question 5

The scientist calculated the mean thickness of the uterus lining.

First, the scientist added together the measurements for all the rats in a group.

For the control group, the total was 4500 micrometres.

Calculate how many rats were in the control group.

Use Table 1.

[2]
Reveal mark scheme Mark scheme for question 5.3
5.4

Complete the sentence.

Choose the answer from the box.

Figure for question 5

The mean thickness of the uterus lining in the two groups in Table 1 was compared.

In rats fed chemical X, the mean thickness of the uterus lining

[1]
Reveal mark scheme Mark scheme for question 5.4
5.5

Some food packaging contains chemical Y.

Chemical Y decreases antibody production in humans.

Food packaging in landfill can release chemical Y into streams, rivers and lakes.

Which are two reasons why food packaging containing chemical Y is a problem?

Tick (✓) two boxes.

Chemical Y could become a fossil fuel.

Chemical Y could contaminate drinking water.

Chemical Y could get into food.

Chemical Y does not dissolve in water.

Chemical Y will be broken down quickly.

[2]
Reveal mark scheme Mark scheme for question 5.5
5.6

Which risk increases when a person produces fewer antibodies?

Tick (✓) one box.

Developing Type 1 diabetes

Getting lung cancer due to mutations

Not being able to recover from infections

[1]
Reveal mark scheme Mark scheme for question 5.6
5.7

If a pathogen enters the body, white blood cells can engulf and digest the pathogen.

What is the name of the process where white blood cells engulf and digest a pathogen?

[1]
Reveal mark scheme Mark scheme for question 5.7
5.8

The pathogen is digested by white blood cells.

Which of the following digests large molecules into smaller molecules?

Tick (✓) one box.

Carbohydrates

Enzymes

Lipids

[1]
Reveal mark scheme Mark scheme for question 5.8

Paper 1: Life and environmental sciences June 2025 Foundation tier, Question 7 12 marks

Doctors sometimes advise people with kidney disease to eat a diet that is low in protein.

7.1

How does a diet that is low in protein help people with kidney disease?

Tick (✓) one box.

Fewer amino acids will break down to form urea.

More urea will be produced and excreted in urine.

Protease will be needed to digest the protein into amino acids.

[1]
Reveal mark scheme Mark scheme for question 7.1
7.2
Figure for question 7
[1]
Reveal mark scheme Mark scheme for question 7.2
7.3

Table 2 shows information about two types of bread.

Figure for question 7

Compare the mass of each nutrient in wholemeal bread with the mass of each nutrient in low-protein bread.

Use Table 2.

[2]
Reveal mark scheme Mark scheme for question 7.3
7.4

Lipidsmaths symbol

One slice of low-protein bread has a mass of 40 g.

Calculate the mass of carbohydrate in the slice of bread.

Use Table 2.

[2]
Reveal mark scheme Mark scheme for question 7.4
7.5

A person eats some bread.

Describe how carbohydrates and lipids from the bread are broken down and used in cells.

You should include:

maths symbol the enzymes involved

maths symbol the molecules formed

maths symbol how the molecules are used in cells.

[6]
Reveal mark scheme Mark scheme for question 7.5

Paper 2: Life and environmental sciences June 2024 Higher tier, Question 8 11 marks

Funnel-web spiders produce a poison to kill prey.

The poison enters the prey when the spider bites the prey.

The poison contains a protein.

8.1
Figure for question 8 Figure for question 8
[2]
Reveal mark scheme Mark scheme for question 8.1
8.2

Animals produce protease enzymes.

Explain why protease enzymes do not protect animals that are bitten by funnel-web spiders.

[2]
Reveal mark scheme Mark scheme for question 8.2
8.3

The protein from the poison may be used in a new drug.

The protein allows heart muscle tissue to function in low concentrations of oxygen.

Explain how coronary heart disease can decrease the concentration of oxygen in heart muscle tissue.

[2]
Reveal mark scheme Mark scheme for question 8.3
8.4

The new drug may be useful when transporting a donor heart to a patient for a heart transplant.

Suggest why.

[1]
Reveal mark scheme Mark scheme for question 8.4
8.5

The species of funnel-web spider that produces the poison comes from a small, remote area.

Evaluate the use of the poison from the funnel-web spider as a drug.

[4]
Reveal mark scheme Mark scheme for question 8.5

Paper 2: Life and environmental sciences June 2023 Foundation tier, Question 4 12 marks

Starch molecules are broken down into glucose molecules in the small intestine (gut).

The glucose molecules are absorbed across the wall of the small intestine into the blood.

Figure 9 shows part of the wall of the small intestine.

Figure for question 4
4.1

Give two ways that the small intestine is adapted for the absorption of glucose into the blood.

Use Figure 9.

[2]
Reveal mark scheme Mark scheme for question 4.1
4.2

Figure 10 shows:

maths symbol the breakdown of starch molecules

maths symbol the movement of glucose molecules across the wall of the small intestine.

Figure for question 4 Figure for question 4 Figure for question 4 Figure for question 4
[3]
Reveal mark scheme Mark scheme for question 4.2
4.3

Give one reason why starch molecules cannot be absorbed into the blood.

Use Figure 10.

[1]
Reveal mark scheme Mark scheme for question 4.3
4.4

A student investigated the breakdown of starch with an enzyme and without an enzyme.

Figure 11 shows the apparatus.

Figure for question 4

This is the method used.

1. Add 5 cm3 of starch and enzyme mixture to a test tube.

2. Place the test tube into a water bath at 37 °C.

3. Remove one drop of the mixture every 60 seconds and test for starch using iodine solution.

4. Repeat step 3 until the starch is broken down or until 20 minutes is reached.

5. Repeat steps 1 to 4 another three times.

6. Repeat steps 1 to 5 using 5 cm3 of starch solution with no enzyme.

What colour will the iodine solution change to when starch is present?

Tick (✓) one box.

Black

Orange

Red

White

[1]
Reveal mark scheme Mark scheme for question 4.4
4.5

What is the dependent variable in this investigation?

Tick (✓) one box.

Temperature of the water bath

Time taken for starch to break down

Volume of the sample tested

[1]
Reveal mark scheme Mark scheme for question 4.5
4.6

Table 2 shows the results for the starch and enzyme mixture.

Figure for question 4

One of the results in Table 2 is anomalous.

Which result is anomalous?

Tick (✓) one box.

300 s
420 s 60 s
360 s

[1]
Reveal mark scheme Mark scheme for question 4.6
4.7

What should the student do with the anomalous result?

[1]
Reveal mark scheme Mark scheme for question 4.7
4.8

The student removed one drop of the mixture every 60 seconds and tested the drop for starch.

How could the student improve the method?

Tick (✓) one box.

Test for starch every 30 seconds

Test for starch every 3 minutes

Test for starch every 10 minutes

[1]
Reveal mark scheme Mark scheme for question 4.8
4.9

Another student repeated the investigation.

Table 3 shows the results.

Figure for question 4

Give one conclusion that can be made from the results.

[1]
Reveal mark scheme Mark scheme for question 4.9

Paper 2: Life and environmental sciences June 2023 Higher tier, Question 3 10 marks

The small intestine (gut) is adapted to digest and absorb food molecules.

Digested food molecules pass across the wall of the small intestine into the blood.

Figure 5 shows part of the wall of the small intestine.

Figure for question 3
3.1
Figure for question 3 Figure for question 3
[2]
Reveal mark scheme Mark scheme for question 3.1
3.2

A student used partially permeable tubing to make a model of a human small intestine.

Figure 6 shows the apparatus used.

Figure for question 3

This is the method used.

1. Add starch and enzyme solution to the tubing.

2. Take a sample of the mixture from inside the tubing and a sample of the water from the test tube. Test each sample:

maths symbol using the iodine test

maths symbol using the Benedict’s test.

3. Place the test tube into a water bath at 37 °C.

4. Repeat step 2 after 30 minutes.

What type of enzyme breaks down starch?

[1]
Reveal mark scheme Mark scheme for question 3.2
3.3

The water bath was kept at 37 °C.

Explain why 37 °C was the most suitable temperature for the investigation.

[2]
Reveal mark scheme Mark scheme for question 3.3
3.4

Table 3 shows the results.

Figure for question 3

Explain the results for test 3.

[2]
Reveal mark scheme Mark scheme for question 3.4
3.5

Explain the results for test 4.

[3]
Reveal mark scheme Mark scheme for question 3.5

Paper 1: Life and environmental sciences June 2022 Foundation tier, Question 10 18 marks

Students investigated the effect of different concentrations of salt solution on the mass of pieces of potato.

This is the method used.

1. Cut three pieces of potato, each with a mass of 2.00 g.

2. Place the pieces of potato into a salt solution with a concentration of 0.2 mol/dm3

3. After 30 minutes, measure the mass of each piece of potato.

4. Calculate the change in mass.

5. Repeat steps 1 to 4 for five other concentrations of salt solution.

Table 3 shows the results.

Figure for question 10
10.1

Give two control variables the students should have used in the investigation.

Do not refer to mass or time in your answer.

[2]
Reveal mark scheme Mark scheme for question 10.1
10.2

Calculate value X in Table 3.

[3]
Reveal mark scheme Mark scheme for question 10.2
10.3

Figure 14 shows a potato cell.

Figure for question 10

Explain why the mass of the pieces of potato increased in the 0.2 mol/dm3 salt solution.

You should refer to the cell parts labelled in Figure 14.

[6]
Reveal mark scheme Mark scheme for question 10.3
10.4

The image in Figure 14 was made using an electron microscope and not a light microscope.

Give one piece of evidence to support this.

[1]
Reveal mark scheme Mark scheme for question 10.4
10.5
Figure for question 10 Figure for question 10
[3]
Reveal mark scheme Mark scheme for question 10.5
10.6

Starch is digested in the gut.

Why is digestion of starch needed?

Tick (✓) one box.

Starch is a carbohydrate.

Starch molecules are insoluble.

Starch molecules are small.

[1]
Reveal mark scheme Mark scheme for question 10.6
10.7

Describe the process of starch digestion.

[2]
Reveal mark scheme Mark scheme for question 10.7

Paper 1: Life and environmental sciences June 2022 Higher tier, Question 2 18 marks

Students investigated the effect of different concentrations of salt solution on the mass of pieces of potato.

This is the method used.

1. Cut three pieces of potato, each with a mass of 2.00 g.

2. Place the pieces of potato into a salt solution with a concentration of 0.2 mol/dm3

3. After 30 minutes, measure the mass of each piece of potato.

4. Calculate the change in mass.

5. Repeat steps 1 to 4 for five other concentrations of salt solution.

Table 1 shows the results.

Figure for question 2
2.1

Give two control variables the students should have used in the investigation.

Do not refer to mass or time in your answer.

[2]
Reveal mark scheme Mark scheme for question 2.1
2.2

Calculate value X in Table 1.

[3]
Reveal mark scheme Mark scheme for question 2.2
2.3

Figure 2 shows a potato cell.

Figure for question 2

Explain why the mass of the pieces of potato increased in the 0.2 mol/dm3 salt solution.

You should refer to the cell parts labelled in Figure 2.

[6]
Reveal mark scheme Mark scheme for question 2.3
2.4

The image in Figure 2 was made using an electron microscope and not a light microscope.

Give one piece of evidence to support this.

[1]
Reveal mark scheme Mark scheme for question 2.4
2.5
Figure for question 2 Figure for question 2
[3]
Reveal mark scheme Mark scheme for question 2.5
2.6

Starch is digested in the gut.

Why is digestion of starch needed?

Tick (✓) one box.

Starch is a carbohydrate.

Starch molecules are insoluble.

Starch molecules are small.

[1]
Reveal mark scheme Mark scheme for question 2.6
2.7

Describe the process of starch digestion.

[2]
Reveal mark scheme Mark scheme for question 2.7

Paper 2: Life and environmental sciences November 2021 Foundation tier, Question 5 14 marks

Proteins are an important part of the human diet.

5.1

Proteins are large food molecules that must be broken down in the digestive system.

Which enzyme breaks down proteins?

Tick (✓) one box.

Carbohydrase

Lipase

Protease

[1]
Reveal mark scheme Mark scheme for question 5.1
5.2

Proteins are digested into amino acids.

The body breaks down unwanted amino acids.

Which organ breaks down unwanted amino acids?

Tick (✓) one box.

Brain Liver Lung

[1]
Reveal mark scheme Mark scheme for question 5.2
5.3

What is produced by the breakdown of unwanted amino acids?

Tick (✓) one box.

Fat Starch Urea

[1]
Reveal mark scheme Mark scheme for question 5.3
5.4

Mycoprotein is a protein made from a fungus.

Table 3 shows information about mycoprotein sausages and meat sausages.

Figure for question 5

Give three differences between the nutrient content of mycoprotein sausages and meat sausages.

[3]
Reveal mark scheme Mark scheme for question 5.4
5.5

A student tested the mycoprotein sausage and the meat sausage for protein.

What is used to test for protein?

Tick (✓) one box.

Biuret reagent

Iodine solution

pH indicator solution

[1]
Reveal mark scheme Mark scheme for question 5.5
5.6

What colour is the positive result for the test for protein?

Tick (✓) one box.

Black

Lilac

Red

White

[1]
Reveal mark scheme Mark scheme for question 5.6
5.7

The student investigated the sugar content of the mycoprotein sausage and the meat sausage.

Figure 8 shows some of the apparatus used.

Figure for question 5

Describe a method to compare the amount of sugar in the two types of sausage.

Use the apparatus in Figure 8 in your answer.

[6]
Reveal mark scheme Mark scheme for question 5.7

Paper 2: Life and environmental sciences November 2021 Higher tier, Question 3 14 marks

Fat, protein and carbohydrate are important parts of the human diet.

Table 3 shows information for cow’s milk and three plant-based milks.

Figure for question 3
3.1

The different types of milk in Table 3 can be bought in bottles.

Suggest why the nutritional information is given as ‘grams per 100 grams’ of milk instead of ‘grams per bottle’.

[1]
Reveal mark scheme Mark scheme for question 3.1
3.2

Suggest which milk in Table 3 has the greatest energy content.

Give one reason for your answer.

[2]
Reveal mark scheme Mark scheme for question 3.2
3.3

A student added iodine solution to each milk.

Explain why only the oat milk and the soy milk turned blue-black.

Use Table 3.

[2]
Reveal mark scheme Mark scheme for question 3.3
3.4

A student tested samples of the different milks for sugar.

This is the method used.

1. Add 1.0 cm3 of the milk sample to a test tube.

2. Add 1.0 cm3 of water and 2.0 cm3 of Benedict’s solution.

3. Place the test tube in a water bath at 80 °C.

4. Record the colour of the mixture at the end of the test.

5. Repeat steps 1 to 4 for the other milk samples.

The volume of each mixture in the test tube and the temperature of the water bath were control variables.

Give one other variable that should have been a control variable.

Do not refer to volume or temperature in your answer.

[1]
Reveal mark scheme Mark scheme for question 3.4
3.5

What was the dependent variable in the investigation?

[1]
Reveal mark scheme Mark scheme for question 3.5
3.6

To improve the method the student set up a control test tube.

What should the student add to the control test tube?

[1]
Reveal mark scheme Mark scheme for question 3.6
3.7

The fat in milk is broken down in the digestive system.

Describe the breakdown of fat in the digestive system.

[2]
Reveal mark scheme Mark scheme for question 3.7
3.8

Explain why the fat in milk needs to be broken down before it can be used in the body.

[2]
Reveal mark scheme Mark scheme for question 3.8
3.9

Protein in milk is broken down into amino acids.

Describe how unwanted amino acids are processed and removed from the body.

[2]
Reveal mark scheme Mark scheme for question 3.9

Paper 1: Life and environmental sciences November 2020 Foundation tier, Question 9 15 marks

Sewers are often blocked by ‘fatbergs’.

Fatbergs are made of very large lumps of fat and other solids.

The fat and solids come from waste being washed down drains and flushed down toilets.

Figure 11 shows a person holding a small fatberg.

Figure for question 9
9.1

The chemical composition of fatbergs can be tested.

Describe how a sample from a fatberg could be tested for fat and for protein.

Positive result for fat

Positive result for protein

[4]
Reveal mark scheme Mark scheme for question 9.1
9.2

Some fats in fatbergs come from undigested food in faeces.

Most fat that humans eat is digested.

Give the two products of fat digestion.

[2]
Reveal mark scheme Mark scheme for question 9.2
9.3

It may be possible to use fatbergs as a fuel in power stations.

Burning 1.0 kg of fatbergs transfers 40 MJ of energy.

A power station could burn 1250 kg of fatbergs each hour.

Calculate the energy output from the power station in 1 year.

1 year = 8760 hours

Energy output in 1 year = MJ

[3]
Reveal mark scheme Mark scheme for question 9.3
9.4

Evaluate burning fatbergs in power stations compared with burning coal in power stations.

[6]
Reveal mark scheme Mark scheme for question 9.4

Paper 1: Life and environmental sciences November 2020 Higher tier, Question 3 15 marks

Sewers are often blocked by ‘fatbergs’.

Fatbergs are made of very large lumps of fat and other solids.

The fat and solids come from waste being washed down drains and flushed down toilets.

Figure 2 shows a person holding a small fatberg.

Figure for question 3
3.1

The chemical composition of fatbergs can be tested.

Describe how a sample from a fatberg could be tested for fat and for protein.

Positive result for fat

Positive result for protein

[4]
Reveal mark scheme Mark scheme for question 3.1
3.2

Some fats in fatbergs come from undigested food in faeces.

Most fat that humans eat is digested.

Give the two products of fat digestion.

[2]
Reveal mark scheme Mark scheme for question 3.2
3.3

It may be possible to use fatbergs as a fuel in power stations.

Burning 1.0 kg of fatbergs transfers 40 MJ of energy.

A power station could burn 1250 kg of fatbergs each hour.

Calculate the energy output from the power station in 1 year.

1 year = 8760 hours

Question 3, shown as an image
[3]
Reveal mark scheme Mark scheme for question 3.3
3.4

Evaluate burning fatbergs in power stations compared with burning coal in power stations.

[6]
Reveal mark scheme Mark scheme for question 3.4

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