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Edexcel GCSE Combined Science

Topic questions Human physiology The heart & circulation

The heart & circulation

15 questions · 158 marks · about 3 hours

The heart and circulation questions

Edexcel 1SC0 The heart and circulation 15 questions

Paper 2: Biology 2 June 2025 Foundation tier, Question 4 11 marks

Figure 7 shows the structure of the human heart and the direction of blood flow.

Figure for question 4
(a)
(a)(i)

Measure the thickness of the left ventricle wall between points T and U.

[1]
Reveal mark scheme Mark scheme for question 4(a)(i)
(a)(ii)

Describe how deoxygenated blood leaves the right side of the heart and becomes oxygenated.

[2]
Reveal mark scheme Mark scheme for question 4(a)(ii)
(a)(iii)

Which blood vessel returns deoxygenated blood to the right side of the heart?

Question 4, shown as an image
[1]
Reveal mark scheme Mark scheme for question 4(a)(iii)
(b)

Figure 7 shows the valves that stop blood from flowing in the wrong direction.

State the number of valves in the right side of the human heart shown in Figure 7.

[1]
Reveal mark scheme Mark scheme for question 4(b)
(c)

The heart is part of the circulatory system.

Describe what happens to the blood when the left ventricle contracts.

[3]
Reveal mark scheme Mark scheme for question 4(c)
(d)

Figure 8 shows information about three types of blood vessel.

Figure for question 4
(d)(i)

State the type of blood vessel shown as C in Figure 8.

[1]
Reveal mark scheme Mark scheme for question 4(d)(i)
(d)(ii)

Describe how the structure of a capillary helps gas exchange in the lungs.

[2]
Reveal mark scheme Mark scheme for question 4(d)(ii)

Paper 2: Biology 2 June 2025 Foundation tier, Question 5 11 marks

(a)

Explain why a person's heart rate increases when they are running compared with when they are at rest.

[2]
Reveal mark scheme Mark scheme for question 5(a)
(b)

Figure 9 shows a diagram of mucus‑producing goblet cells and ciliated epithelial cells in the airways of the lungs.

Figure for question 5

(Source: © K.K.T Madhusanka/Shutterstock)

Figure 9

Describe how pathogens are removed from the airways by ciliated epithelial cells.

[2]
Reveal mark scheme Mark scheme for question 5(b)
(c)

During a race, athletes respire aerobically and anaerobically.

Figure 10 shows an athlete after a race.

Figure for question 5

Explain how aerobic respiration provides energy for running.

[2]
Reveal mark scheme Mark scheme for question 5(c)
(d)

The rate of respiration of maggots was investigated using the equipment shown in Figure 11.

Figure for question 5
(d)(i)

State the reason why the soda lime is placed in the test tube.

[1]
Reveal mark scheme Mark scheme for question 5(d)(i)
(d)(ii)

The drop of liquid in Figure 11 is at 20 mm.

The drop of coloured liquid moved at a mean rate of 2 mm per minute.

Draw, on Figure 12, the new position of the bubble after the five minutes.

Figure for question 5
[1]
Reveal mark scheme Mark scheme for question 5(d)(ii)
(d)(iii)

The investigation was repeated with two maggots.

Explain how the movement of the drop of coloured liquid would be affected if the investigation was repeated using fewer maggots.

[2]
Reveal mark scheme Mark scheme for question 5(d)(iii)
(d)(iv)

State one way this investigation can be improved to obtain more reliable results.

[1]
Reveal mark scheme Mark scheme for question 5(d)(iv)

Paper 2: Biology 2 June 2025 Higher tier, Question 5 12 marks

Also involves Percentages

(a)

Figure 9 is a diagram of the human heart.

Figure for question 5
(a)(i)

Which chambers of the heart contain only oxygenated blood?

Question 5, shown as an image
[1]
Reveal mark scheme Mark scheme for question 5(a)(i)
(a)(ii)

The heart has a valve called the bicuspid valve between chamber Q and chamber R.

Explain the role of this valve.

[2]
Reveal mark scheme Mark scheme for question 5(a)(ii)
(b)

Explain why heart rate increases during exercise.

[3]
Reveal mark scheme Mark scheme for question 5(b)
(c)
(c)(i)

Every person has a maximum heart rate.

Figure 10 shows how different types of activity affect a person’s heart rate and the type of respiration they are using during that activity.

Figure for question 5

A person had a maximum heart rate of 190 beats per minute. Calculate the heart rate of this person when they are jogging.

Give your answer to 3 significant figures.

........ beats per minute

[3]
Reveal mark scheme Mark scheme for question 5(c)(i)
(c)(ii)

Erythrocytes (red blood cells) transport oxygen to respiring cells.

Explain how erythrocytes (red blood cells) are adapted to carry and release oxygen.

[3]
Reveal mark scheme Mark scheme for question 5(c)(ii)

Paper 2: Biology 2 June 2024 Foundation tier, Question 4 11 marks

In humans, gas exchange occurs in the alveoli of the lungs.

Figure 6 shows the structure of an alveolus and its blood supply.

Figure for question 4
(a)

Which process moves carbon dioxide from the blood into the alveolus?

Question 4, shown as an image
[1]
Reveal mark scheme Mark scheme for question 4(a)
(b)

State one adaptation of an alveolus that increases the rate of gas exchange.

[1]
Reveal mark scheme Mark scheme for question 4(b)
(c)

Describe how blood is moved from the heart to the lungs.

[2]
Reveal mark scheme Mark scheme for question 4(c)
(d)

Figure 7 shows the heart rate of a person before, during and after exercise.

Figure for question 4
(d)(i)

Describe the trend shown in Figure 7.

Use data from Figure 7 to support your answer.

[2]
Reveal mark scheme Mark scheme for question 4(d)(i)
(d)(ii)

Explain the trend shown in Figure 7 from 5 minutes to 25 minutes.

[2]
Reveal mark scheme Mark scheme for question 4(d)(ii)
(d)(iii)

The stroke volume is the volume of blood pumped during one beat of the heart.

At 25 minutes the stroke volume was 0.13 dm3.

Calculate the cardiac output of the heart of this person at 25 minutes.

Use the equation

cardiac output = stroke volumemaths symbolheart rate

........ dm3 per minute

[3]
Reveal mark scheme Mark scheme for question 4(d)(iii)

Paper 2: Biology 2 June 2024 Foundation tier, Question 5 11 marks

(a)

The heart pumps blood.

Explain why the wall of the left ventricle of the heart is thicker than the wall of the right ventricle of the heart.

[2]
Reveal mark scheme Mark scheme for question 5(a)
(b)

A centrifuge can be used to separate the different parts of human blood.

Figure 8 shows blood separated into different parts.

Figure for question 5
(b)(i)

Name part X.

[1]
Reveal mark scheme Mark scheme for question 5(b)(i)
(b)(ii)

Which substance, needed for cellular respiration, is carried by red blood cells?

Question 5, shown as an image
[1]
Reveal mark scheme Mark scheme for question 5(b)(ii)
(b)(iii)

Name two types of white blood cell.

[2]
Reveal mark scheme Mark scheme for question 5(b)(iii)
(c)
(c)(i)

When a person donates blood, 470 cm3 of blood is removed from their body.

Red blood cells make up 44% by volume of the blood.

Calculate the volume of red blood cells in 470 cm3 of donated blood.

Give your answer to the nearest whole number.

........ cm3

[3]
Reveal mark scheme Mark scheme for question 5(c)(i)
(c)(ii)

Before donating blood, a person has a small blood sample taken to check that the blood is healthy.

State two precautions a doctor should take when collecting this sample.

[2]
Reveal mark scheme Mark scheme for question 5(c)(ii)

Paper 2: Biology 2 June 2024 Higher tier, Question 5 11 marks

(a)

Figure 6 shows a human heart.

Figure for question 5
(a)(i)

Draw arrows on Figure 6 to show the direction of blood flow through the left side of the heart.

[2]
Reveal mark scheme Mark scheme for question 5(a)(i)
(a)(ii)

Name the main blood vessel that carries deoxygenated blood into the heart.

[1]
Reveal mark scheme Mark scheme for question 5(a)(ii)
(b)

Figure 7 shows the heart rate and stroke volume of a person when at rest and when doing exercise.

Figure for question 5
(b)(i)

Calculate the difference in cardiac output when at rest and when doing exercise.

Give your answer to 3 significant figures and include units in your answer.

........

[4]
Reveal mark scheme Mark scheme for question 5(b)(i)
(b)(ii)

Explain why the cardiac output needs to increase during exercise.

[4]
Reveal mark scheme Mark scheme for question 5(b)(ii)

Paper 2: Biology 2 June 2023 Foundation tier, Question 2 9 marks

Figure 4 shows a diagram of the human blood system.

Figure for question 2
(a)
(a)(i)

Name blood vessel X.

[1]
Reveal mark scheme Mark scheme for question 2(a)(i)
(a)(ii)

Which row of the table shows the width of the wall and blood pressure in blood vessel X?

Figure for question 2
[1]
Reveal mark scheme Mark scheme for question 2(a)(ii)
(b)

Figure 5 shows the pressure of blood flowing through the arteries, capillaries and veins of a person.

Figure for question 2

Calculate the difference in blood pressure from the maximum in the arteries to the minimum in the veins.

........ kPa

[2]
Reveal mark scheme Mark scheme for question 2(b)
(c)

Figure 6 shows a diagram of a vein with blood cells.

Figure for question 2
(c)(i)

Identify structure Q.

[1]
Reveal mark scheme Mark scheme for question 2(c)(i)
(c)(ii)

State the function of structure Q.

[1]
Reveal mark scheme Mark scheme for question 2(c)(ii)
(d)

Describe how the heart causes blood to move to the lungs.

[3]
Reveal mark scheme Mark scheme for question 2(d)

Paper 2: Biology 2 June 2022 Foundation tier, Question 6 13 marks

(a)

Figure 11 shows a cross-section of an artery and a vein.

Figure for question 6

(Source: © The University of Kansas Medical Center)

Figure 11

(a)(i)

Explain one difference between the artery wall and the vein wall shown in Figure 11.

[2]
Reveal mark scheme Mark scheme for question 6(a)(i)
(a)(ii)

Name one structure that is found in veins but not found in arteries.

[1]
Reveal mark scheme Mark scheme for question 6(a)(ii)
(b)

A human body has 5 dm3 of blood.

At rest 20% of the blood travels to the muscles.

During exercise 60% of the blood travels to the muscles.

(b)(i)

Calculate the volume of blood travelling to the muscles during exercise.

........ dm3

[2]
Reveal mark scheme Mark scheme for question 6(b)(i)
(b)(ii)

Explain one reason why there is an increase in blood flow to muscles during exercise.

[2]
Reveal mark scheme Mark scheme for question 6(b)(ii)
(c)

*(c) Figure 12 shows the structure of the human heart.

Figure for question 6

Explain how the structure of the heart is related to its function.

[6]
Reveal mark scheme Mark scheme for question 6(c)

Paper 2: Biology 2 June 2022 Higher tier, Question 5 12 marks

The effect of different types of exercise on the heart rate of an athlete was investigated.

The athlete counted the number of beats in 10 seconds at the carotid artery pulse point, as shown in Figure 7.

This measurement was used to calculate the heart rate.

Figure for question 5

The athlete exercised for 20 minutes.

The heart rate was recorded every 5 minutes during each type of exercise.

(a)(i)

State how the heart rate was calculated using this method.

[1]
Reveal mark scheme Mark scheme for question 5(a)(i)
(a)(ii)

Give two ways of improving the method used to obtain the data needed to calculate the heart rate.

[2]
Reveal mark scheme Mark scheme for question 5(a)(ii)
(a)(iii)

Figure 8 shows the results of this investigation.

Figure for question 5

Comment on the difference in the heart rates during these types of exercise.

[3]
Reveal mark scheme Mark scheme for question 5(a)(iii)
(b)

Exercise increases adrenalin levels.

(b)(i)

State which endocrine gland secretes adrenalin.

[1]
Reveal mark scheme Mark scheme for question 5(b)(i)
(b)(ii)

Explain the effect of adrenalin on liver cells during exercise.

[3]
Reveal mark scheme Mark scheme for question 5(b)(ii)
(c)

After high intensity exercise, the pH of muscles can decrease from pH 7.0 to pH 6.3.

Explain this change in pH.

[2]
Reveal mark scheme Mark scheme for question 5(c)

Paper 2: Biology 2 November 2020 Foundation tier, Question 1 7 marks

Figure 1 shows a diagram of the heart.

Figure for question 1
Question 1, shown as an image

Figure 1

(a)(i)

Draw arrows on Figure 1 to show how oxygenated blood moves through the heart.

[1]
Reveal mark scheme Mark scheme for question 1(a)(i)
(a)(ii)

What happens when the right ventricle contracts?

Question 1, shown as an image
[1]
Reveal mark scheme Mark scheme for question 1(a)(ii)
(a)(iii)

Draw one straight line from each structure to its function.

Figure for question 1
[2]
Reveal mark scheme Mark scheme for question 1(a)(iii)
(b)

Figure 2 shows a dissected vein.

Figure for question 1
(b)(i)

Explain how the valves in veins help the blood, at low pressure, flow towards the heart.

[2]
Reveal mark scheme Mark scheme for question 1(b)(i)
(b)(ii)

The equipment used to dissect the vein was cleaned and put into disinfectant.

State why this equipment was put into disinfectant.

[1]
Reveal mark scheme Mark scheme for question 1(b)(ii)

Paper 2: Biology 2 November 2020 Higher tier, Question 5 10 marks

Figure 8 shows the heart rate of person A and person B.

Person A does not do any regular exercise.

Person B has been running regularly for one year.

Figure for question 5
(a)

Both people rested for the first 6 minutes, then did the same high intensity exercise for the next 12 minutes, then rested.

Compare the heart rates of person A with the heart rates of person B.

[4]
Reveal mark scheme Mark scheme for question 5(a)
(b)

The stroke volume for person B before exercising was 61 ml per beat.

Calculate the cardiac output for person B before exercising.

Give your answer in litres per minute.

........ litres per minute

[3]
Reveal mark scheme Mark scheme for question 5(b)
(c)

The cardiac output for person A during exercise was 5.5 litres per minute.

Explain why the heart rate for person A needed to be higher than the heart rate for person B during exercise.

[3]
Reveal mark scheme Mark scheme for question 5(c)

Paper 2: Biology 2 June 2019 Foundation tier, Question 3 9 marks

(a) Figure 5 shows a cross section of an artery and a vein.

Figure for question 3

(Source: © The University of Kansas Medical Center)

Figure 5

(a)
(a)(i)

Measure the length of line A and the length of line B in mm.

line A........ mm

line B........ mm

[1]
Reveal mark scheme Mark scheme for question 3(a)(i)
(a)(ii)

State the ratio of the thickness of the artery wall to the thickness of the vein wall.

[1]
Reveal mark scheme Mark scheme for question 3(a)(ii)
(b)(i)

Give a reason why veins have valves.

[1]
Reveal mark scheme Mark scheme for question 3(b)(i)
(b)(ii)

Name the artery that transports oxygenated blood from the heart to the body.

[1]
Reveal mark scheme Mark scheme for question 3(b)(ii)
(c)

A scientist investigated the relationship between exercise and the ability to run at 3 metres per second for 20 minutes.

The scientist collected data from six groups of people. Each group exercised for a different number of hours per week for six months.

There were 100 people in each group.

Figure 6 shows their results.

groupnumber of hours of exercise per weeknumber of people who could run at 3 metres per second for 20 minutes
A09
B220
C433
D652
E861
F1062
Question 3, shown as an image
(c)(i)

Describe the relationship shown by this data.

[2]
Reveal mark scheme Mark scheme for question 3(c)(i)
(c)(ii)

Explain why some people’s leg muscles tired quickly and developed cramp when they were running.

[3]
Reveal mark scheme Mark scheme for question 3(c)(ii)

Paper 2: Biology 2 June 2019 Higher tier, Question 5 11 marks

(a) Figure 5 shows the stroke volume at different heart rates of a person who has trained for a marathon and of a person who has not trained for a marathon.

Figure for question 5
(a)
(a)(i)

Compare the effect of heart rate on stroke volume of the person who has trained for a marathon with the person who has not trained for a marathon.

[2]
Reveal mark scheme Mark scheme for question 5(a)(i)
(a)(ii)

Calculate the cardiac output for the person who has trained for a marathon when the heart rate is 160 beats per minute. Give the units in your answer.

[3]
Reveal mark scheme Mark scheme for question 5(a)(ii)
(b)

*(b) Blood from the body enters the heart through the vena cava.

Describe how this blood flows through the heart and lungs to leave the heart through the aorta.

Include references to the chambers of the heart and the relevant valves in your answer.

[6]
Reveal mark scheme Mark scheme for question 5(b)

Paper 2: Biology 2 June 2018 Foundation tier, Question 5 12 marks

(a) Figure 9 shows a diagram of a red blood cell from a turtle and a diagram of a red blood cell from a human.

Figure for question 5
(a)
(a)(i)

These cells are animal cells.

Animal cells do not have

Question 5, shown as an image
[1]
Reveal mark scheme Mark scheme for question 5(a)(i)
(a)(ii)

The actual length of the red blood cell from a turtle is 20.5 μ m.

Calculate the length of the magnified image of the red blood cell of the turtle when magnified 400 ×.

........ μm

[2]
Reveal mark scheme Mark scheme for question 5(a)(ii)
(a)(iii)

The width of the human red blood cell, when magnified 400 ×, is 3.08 mm.

Calculate the actual width of the cell and show your answer in standard form.

........ mm

[2]
Reveal mark scheme Mark scheme for question 5(a)(iii)
(b)

Red blood cells are carried in veins and arteries.

Figure 10 shows the equipment used to measure the elasticity of an artery.

Figure for question 5
(b)(i)

Describe a method you could use to see how much the ring of tissue from an artery could stretch before it no longer returned to its original size.

[3]
Reveal mark scheme Mark scheme for question 5(b)(i)
(b)(ii)

Give one safety precaution you need to take when handling animal tissue such as blood vessels.

[1]
Reveal mark scheme Mark scheme for question 5(b)(ii)
(c)

Figure 11 shows the circulatory system of a frog.

Figure for question 5

Explain why the circulatory system of a frog is less efficient at carrying oxygen to the tissues than the circulatory system of a human.

[3]
Reveal mark scheme Mark scheme for question 5(c)

Paper 2: Biology 2 June 2018 Higher tier, Question 3 8 marks

Figure 5 shows the estimated blood flow through some parts of the body when a person is at rest and during exercise.

Figure for question 3
(a)

Compare the rate of blood flow through the body when this person is at rest and during exercise.

[3]
Reveal mark scheme Mark scheme for question 3(a)
(b)

Explain why there is a change in the rate of blood flow through the digestive system during exercise.

[2]
Reveal mark scheme Mark scheme for question 3(b)
(c)

The stroke volume is the amount of blood leaving one chamber of the heart per beat.

From which chamber of the heart does this volume of oxygenated blood flow?

Question 3, shown as an image
[1]
Reveal mark scheme Mark scheme for question 3(c)
(d)

A person has a cardiac output of 4.9 litres per minute. The stroke volume of each heart beat is 70 ml.

Calculate the heart rate.

........ beats per minute

[2]
Reveal mark scheme Mark scheme for question 3(d)

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