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Edexcel GCSE Combined Science

Topic questions Cell biology Units and scale in cells

Units and scale in cells

20 questions · 190 marks · about 3.5 hours

Units and scale in cells questions

Edexcel 1SC0 Units and scale in cells 20 questions

Paper 1: Biology 1 June 2025 Higher tier, Question 2 7 marks

(a)

Figure 2 shows a beaker containing a potato cylinder in distilled water.

Figure for question 2

Explain why the mass of this potato cylinder will change when it is placed in distilled water.

[3]
Reveal mark scheme Mark scheme for question 2(a)
(b)

A scientist investigated the rate of diffusion using three agar cubes of different sizes.

Each cube contained a pH indicator that changed from pink to colourless when placed in acid.

The cubes were placed in a beaker containing an acid.

Figure 3 shows some information about each cube.

Figure for question 2
(b)(i)

Calculate the volume of cube C.

[2]
Reveal mark scheme Mark scheme for question 2(b)(i)
(b)(ii)

Explain the difference in the times taken for cubes A and B to become colourless.

[2]
Reveal mark scheme Mark scheme for question 2(b)(ii)

Paper 1: Biology 1 June 2025 Higher tier, Question 4 9 marks

(a)

The pathogen Vibrio cholerae causes the disease cholera.

Figure 5 shows Vibrio cholerae bacteria.

Figure for question 4
(a)(i)

Complete the table to show the function of structure P and structure Q.

Figure for question 4
[2]
Reveal mark scheme Mark scheme for question 4(a)(i)
(a)(ii)

On the original image, the length of one bacterial cell is 12 mm.

The actual length of this bacterial cell is 2.0 µ m.

Calculate the magnification.

[2]
Reveal mark scheme Mark scheme for question 4(a)(ii)
(a)(iii)

State one symptom of the disease caused by Vibrio cholerae.

[1]
Reveal mark scheme Mark scheme for question 4(a)(iii)
(a)(iv)

State how the disease caused by Vibrio cholerae is transmitted.

[1]
Reveal mark scheme Mark scheme for question 4(a)(iv)
(b)

Describe the specific immune response when a pathogen infects the body.

[3]
Reveal mark scheme Mark scheme for question 4(b)

Paper 1: Biology 1 June 2024 Higher tier, Question 4 10 marks

(a)

Figure 4 shows images of two stone tools.

Scientists think that tool A was probably used by Homo erectus around 1.6 million years ago.

Tool B was probably used by Homo habilis around 2 million years ago.

Figure for question 4
(a)(i)

Give one reason, using Figure 4, why scientists think that tool A was used by a more recent human ancestor.

[1]
Reveal mark scheme Mark scheme for question 4(a)(i)
(a)(ii)

Describe how scientists can date stone tools using information from where the tools were discovered.

[2]
Reveal mark scheme Mark scheme for question 4(a)(ii)
(b)

Differences in fossilised bones indicate structural changes that have occurred during the evolution of humans.

Describe two structural changes that have occurred during human evolution.

[2]
Reveal mark scheme Mark scheme for question 4(b)
(c)

The migration patterns of humans can be tracked by analysing DNA in mitochondria.

Figure 5 shows a mitochondrion viewed using an electron microscope.

Figure for question 4
(c)(i)

At a magnification of maths symbol62 000 this mitochondrion has a length of 434 mm.

Calculate the actual length of this mitochondrion.

Give your answer in micrometres (µ m).

........ µm

[3]
Reveal mark scheme Mark scheme for question 4(c)(i)
(c)(ii)

Explain why an electron microscope is used to see mitochondria clearly.

[2]
Reveal mark scheme Mark scheme for question 4(c)(ii)

Paper 1: Biology 1 June 2023 Foundation tier, Question 1 7 marks

(a)

Figure 1 shows an animal cell.

Figure for question 1
(a)(i)

Which part of the cell is labelled Y?

Question 1, shown as an image
[1]
Reveal mark scheme Mark scheme for question 1(a)(i)
(a)(ii)

Which structures are found in the part labelled Z?

Question 1, shown as an image
[1]
Reveal mark scheme Mark scheme for question 1(a)(ii)
(a)(iii)

Name the part of an animal cell where respiration occurs.

[1]
Reveal mark scheme Mark scheme for question 1(a)(iii)
(b)

A microscope can be used to observe the structure of a cell.

Figure 2 shows a microscope.

Figure for question 1
(b)(i)

Give one advantage of using a microscope to look at cells.

[1]
Reveal mark scheme Mark scheme for question 1(b)(i)
(b)(ii)

Draw one straight line from each part of the microscope to its function.

Figure for question 1
[2]
Reveal mark scheme Mark scheme for question 1(b)(ii)
(c)

Figure 3 shows some of the units used when cells and organelles are measured.

Figure for question 1

Give the name of the smallest unit shown in Figure 3.

[1]
Reveal mark scheme Mark scheme for question 1(c)

Paper 1: Biology 1 June 2023 Higher tier, Question 2 7 marks

Figure 2 shows colonies of bacteria growing on an agar plate.

Figure for question 2

Each colony starts as one bacterium.

Every time bacteria reproduce, the number of bacteria in each colony doubles.

(a)

Calculate the number of bacteria in a colony after five hours, if each bacterium reproduces every 30 minutes.

........ bacteria

[2]
Reveal mark scheme Mark scheme for question 2(a)
(b)

Some bacteria are pathogens.

(b)(i)

State the meaning of the term pathogen.

[1]
Reveal mark scheme Mark scheme for question 2(b)(i)
(b)(ii)

Explain why antibiotics can be used to treat bacterial infections.

[2]
Reveal mark scheme Mark scheme for question 2(b)(ii)
(b)(iii)

A rod-shaped bacterium is 0.005 mm long.

A student draws the rod-shaped bacterium.

The bacterium in the drawing is 80 mm long.

Calculate the magnification of this drawing.

magnification =........

[2]
Reveal mark scheme Mark scheme for question 2(b)(iii)

Paper 2: Biology 2 June 2023 Higher tier, Question 4 10 marks

Gas exchange happens in the alveoli in the lungs.

Figure 7 shows an alveolus and a capillary.

Figure for question 4

(adapted from: sciencepics/shutterstock)

Figure 7

(a)
(a)(i)

Name the gas used in respiration that moves from the alveolus into the capillary.

[1]
Reveal mark scheme Mark scheme for question 4(a)(i)
(a)(ii)

Name the gas produced by respiration that moves from the capillary into the alveolus.

[1]
Reveal mark scheme Mark scheme for question 4(a)(ii)
(a)(iii)

The capillary wall is only one cell thick.

Explain how gases move from the alveolus to the capillary.

[3]
Reveal mark scheme Mark scheme for question 4(a)(iii)
(a)(iv)

Explain the advantages of red blood cells passing one at a time through this narrow capillary.

[3]
Reveal mark scheme Mark scheme for question 4(a)(iv)
(b)

The average number of alveoli in each human lung is 280 million.

The surface area of 1 million alveoli is 0.25 m2.

Calculate the total surface area of a human lung.

[2]
Reveal mark scheme Mark scheme for question 4(b)

Paper 2: Biology 2 June 2023 Higher tier, Question 6 12 marks

Figure 9 shows a photomicrograph of two stomata in a leaf.

Figure for question 6
(a)
(a)(i)

The length of one guard cell in this image is 6 mm.

Convert the length of this guard cell into micrometres (µ m).

[1]
Reveal mark scheme Mark scheme for question 6(a)(i)
(a)(ii)

The image has been magnified 150×.

Calculate the actual size of the guard cell.

Give your answer in standard form in mm.

........ mm

[3]
Reveal mark scheme Mark scheme for question 6(a)(ii)
(b)

Explain the role of denitrifying bacteria in the nitrogen cycle.

[2]
Reveal mark scheme Mark scheme for question 6(b)
(c)

*(c) Describe how carbon is cycled through the biotic and abiotic components of an ecosystem.

[6]
Reveal mark scheme Mark scheme for question 6(c)

Paper 2: Biology 2 June 2022 Foundation tier, Question 2 8 marks

(a)

Blood contains red blood cells, white blood cells, plasma and platelets.

(a)(i)

Draw one straight line from each part of the blood to its function.

Figure for question 2

Figure 2 shows some red blood cells.

Figure for question 2
[2]
Reveal mark scheme Mark scheme for question 2(a)(i)
(a)(ii)

State two features that can be seen in the red blood cells in Figure 2.

[2]
Reveal mark scheme Mark scheme for question 2(a)(ii)
(b)

Lymphocytes are white blood cells that produce large amounts of protein.

(b)(i)

Which organelle is needed to produce large amounts of protein?

Question 2, shown as an image
[1]
Reveal mark scheme Mark scheme for question 2(b)(i)
(b)(ii)

A small lymphocyte has a diameter of 10 µ m (micrometres).

A microscope magnifies this lymphocyte 400 times.

Calculate the diameter of the image of the lymphocyte seen using this microscope.

image size........ µm

[2]
Reveal mark scheme Mark scheme for question 2(b)(ii)
(b)(iii)

How many micrometres are in 1 mm (millimetre)?

Question 2, shown as an image
[1]
Reveal mark scheme Mark scheme for question 2(b)(iii)

Paper 2: Biology 2 June 2022 Higher tier, Question 3 9 marks

(a)

Figure 4 shows a cross-section of a root nodule on a leguminous plant.

Bacteria in the root nodule provide the leguminous plant with nitrogen compounds.

The leguminous plant provides the bacteria with sugars.

Figure for question 3

(Source: © Nigel Downer / Science Photo Library)

Figure 4

(a)(i)

Which term describes the relationship between this leguminous plant and the bacteria?

Question 3, shown as an image
[1]
Reveal mark scheme Mark scheme for question 3(a)(i)
(a)(ii)

The width of this root nodule is 7.5 mm.

Give the width in µ m.

[1]
Reveal mark scheme Mark scheme for question 3(a)(ii)
(b)

Figure 5 shows part of the nitrogen cycle.

Question 3, shown as an image
Question 3, shown as an image
(b)(i)

Identify the types of microorganism involved in process X and process Y.

[2]
Reveal mark scheme Mark scheme for question 3(b)(i)
(b)(ii)

Explain how crop rotation increases nitrate levels in the soil.

[3]
Reveal mark scheme Mark scheme for question 3(b)(ii)
(b)(iii)

Explain why increased nitrate levels in the soil improve crop yield.

[2]
Reveal mark scheme Mark scheme for question 3(b)(iii)

Paper 1: Biology 1 November 2021 Higher tier, Question 3 11 marks

(a)

Figure 4 shows cells from an onion root tip as seen using a light microscope.

Figure for question 3

(Source: © Rattiya Thongdumhyu/Shutterstock)

Figure 4

(a)(i)

Identify the stages of mitosis shown in cell Q and cell R.

[1]
Reveal mark scheme Mark scheme for question 3(a)(i)
(a)(ii)
cell Qcell R
Ametaphaseanaphase
Btelophaseanaphase
Cmetaphaseinterphase
Dtelophaseinterphase

Describe two processes that occur in cells during prophase.

[2]
Reveal mark scheme Mark scheme for question 3(a)(ii)
(a)(iii)

State the term used to describe the process which occurs after mitosis, when the cell divides into two.

[1]
Reveal mark scheme Mark scheme for question 3(a)(iii)
(a)(iv)

The diameter of one cell in Figure 4 is 0.075 mm.

Which is this diameter in µm?

Question 3, shown as an image
[1]
Reveal mark scheme Mark scheme for question 3(a)(iv)
(b)

A student placed a prepared slide on the stage of a light microscope.

Describe how to adjust the microscope to view the slide at a magnification of ×400.

[2]
Reveal mark scheme Mark scheme for question 3(b)
(c)

Arthritis is a condition that occurs when cells in joints get damaged or destroyed.

Stem cell therapy can be used to treat arthritis.

Discuss the benefits and risks of using stem cell therapy to treat arthritis.

[4]
Reveal mark scheme Mark scheme for question 3(c)

Paper 1: Biology 1 November 2021 Higher tier, Question 6 11 marks

(a)

Figure 9 shows a sperm cell.

Figure for question 6

Describe how structure A and structure B enable fertilisation.

structure A

[2]
Reveal mark scheme Mark scheme for question 6(a)
(b)

structure B

Figure 10 shows a human egg cell, magnified ×700.

Figure for question 6

(Source: © Pascal Goetgheluck / Science Photo Library)

Figure 10

Calculate the actual width of the region indicated by the line on Figure 10.

Give your answer in millimetres, in standard form.

[3]
Reveal mark scheme Mark scheme for question 6(b)
(c)

* (c) A student investigated the movement of water.

Hens’ eggs were placed in vinegar for two days to dissolve the shell.

This makes the eggs permeable to water.

The eggs were then weighed and placed in different solutions.

After 24 hours the eggs were weighed again.

Figure 11 shows the results.

Figure for question 6

Evaluate the results of this investigation.

You should include calculations using the data in Figure 11.

[6]
Reveal mark scheme Mark scheme for question 6(c)

Paper 2: Biology 2 November 2021 Foundation tier, Question 1 8 marks

Figure 1 shows human blood seen using a light microscope.

Figure for question 1
(a)(i)

The organelle labelled X controls the activities of the white blood cell.

What is the name of organelle X?

Question 1, shown as an image
[1]
Reveal mark scheme Mark scheme for question 1(a)(i)
(a)(ii)

Use words from the box to complete the sentences.

Figure for question 1

Red blood cells contain the substance........ .

Blood plasma is a........ .

[2]
Reveal mark scheme Mark scheme for question 1(a)(ii)
(a)(iii)

Describe two ways that white blood cells protect the body from disease.

[2]
Reveal mark scheme Mark scheme for question 1(a)(iii)
(b)

Figure 2 shows a white blood cell on a 100 µ m scale.

Figure for question 1

State the width of the white blood cell.

........ µm

[1]
Reveal mark scheme Mark scheme for question 1(b)
(c)

Figure 1 shows human blood seen using a light microscope.

Explain why using an electron microscope shows the structures in the white blood cells more clearly.

[2]
Reveal mark scheme Mark scheme for question 1(c)

Paper 2: Biology 2 November 2021 Higher tier, Question 3 9 marks

Figure 6 shows the structure and actual size of red blood cells (erythrocytes).

Figure for question 3

red blood cells side view of red blood cell (cut)

(Source: © N.Vinoth Narasingam/Shutterstock)

Figure 6

(a)(i)

Calculate the image size of the top view of this red blood cell if this cell is

Question 3, shown as an image

Give your answer in mm.

........ mm

[2]
Reveal mark scheme Mark scheme for question 3(a)(i)
(a)(ii)

Explain how the shape of a red blood cell is related to its function.

[3]
Reveal mark scheme Mark scheme for question 3(a)(ii)
(a)(iii)

State the role of haemoglobin inside the red blood cell.

[1]
Reveal mark scheme Mark scheme for question 3(a)(iii)
(b)

Some blood transfusions contain red blood cells.

Red blood cells are stored in a solution containing 5.0% glucose and 0.9% salt.

Explain why red blood cells cannot be stored in pure water.

[3]
Reveal mark scheme Mark scheme for question 3(b)

Paper 1: Biology 1 November 2020 Foundation tier, Question 1 6 marks

(a)

Figure 1 shows three cells.

Figure for question 1
(a)(i)

What is structure X ?

Question 1, shown as an image
[1]
Reveal mark scheme Mark scheme for question 1(a)(i)
(a)(ii)

The bacterial cell in Figure 1 has a flagellum.

State the function of a flagellum.

[1]
Reveal mark scheme Mark scheme for question 1(a)(ii)
(a)(iii)

Give one other difference between the bacterial cell and the animal cell shown in Figure 1.

[1]
Reveal mark scheme Mark scheme for question 1(a)(iii)
(b)

Substances move into and out of cells.

How does oxygen move into and out of cells?

Question 1, shown as an image
[1]
Reveal mark scheme Mark scheme for question 1(b)
(c)

A plant leaf cell is 0.04 mm long.

Calculate the length of the image after this cell has been magnified 500 times.

length of image =........ mm

[2]
Reveal mark scheme Mark scheme for question 1(c)

Paper 1: Biology 1 June 2019 Foundation tier, Question 5 12 marks

(a)

James Watson and Francis Crick built a model that showed that DNA has a double helix structure.

(a)(i)

Which statement about DNA is correct?

Question 5, shown as an image
[1]
Reveal mark scheme Mark scheme for question 5(a)(i)
(a)(ii)

Figure 6 shows the percentage of each base in human DNA.

Figure for question 5

Describe how this data provides evidence for base pairing in DNA.

[2]
Reveal mark scheme Mark scheme for question 5(a)(ii)
(b)

A scientist obtained a mass of 0.0062 nanograms of DNA from a diploid human cell.

Calculate the mass of DNA the scientist should obtain from a haploid human cell.

Give your answer in picograms.

(1 nanogram = 1000 picograms)

........ picograms

[2]
Reveal mark scheme Mark scheme for question 5(b)
(c)

A student used the method shown in Figure 7 to compare the mass of DNA extracted from strawberry fruit cells and from kiwi fruit cells.

Figure for question 5
(c)(i)

State why ethanol is used.

[1]
Reveal mark scheme Mark scheme for question 5(c)(i)
(c)(ii)

State two variables the student needs to control when using this method to compare the mass of DNA from these two fruits.

[2]
Reveal mark scheme Mark scheme for question 5(c)(ii)
(c)(iii)

The student repeated the experiment.

Give one reason why.

[1]
Reveal mark scheme Mark scheme for question 5(c)(iii)
(d)

Mitosis and meiosis are processes that produce new cells.

Compare the outcomes of mitosis and meiosis.

[3]
Reveal mark scheme Mark scheme for question 5(d)

Paper 1: Biology 1 June 2019 Higher tier, Question 1 9 marks

(a)

A scientist obtained a mass of 0.0062 nanograms of DNA from a diploid human cell.

Calculate the mass of DNA the scientist should obtain from a haploid human cell.

Give your answer in picograms.

(1 nanogram = 1000 picograms)

........ picograms

[2]
Reveal mark scheme Mark scheme for question 1(a)
(b)

A student used the method shown in Figure 1 to compare the mass of DNA extracted from strawberry fruit cells and from kiwi fruit cells.

Figure for question 1
(b)(i)

State why ethanol is used.

[1]
Reveal mark scheme Mark scheme for question 1(b)(i)
(b)(ii)

State two variables the student needs to control when using this method to compare the mass of DNA from these two fruits.

[2]
Reveal mark scheme Mark scheme for question 1(b)(ii)
(b)(iii)

The student repeated the experiment.

Give one reason why.

[1]
Reveal mark scheme Mark scheme for question 1(b)(iii)
(c)

Mitosis and meiosis are processes that produce new cells.

Compare the outcomes of mitosis and meiosis.

[3]
Reveal mark scheme Mark scheme for question 1(c)

Paper 1: Biology 1 June 2019 Higher tier, Question 3 12 marks

(a)

Organisms can be classified by the five kingdom or three domain method.

(a)(i)

What is the name of the domain that plants belong to?

Question 3, shown as an image
[1]
Reveal mark scheme Mark scheme for question 3(a)(i)
(a)(ii)

Plant cells contain chloroplasts.

What happens in a chloroplast?

Figure for question 3
[1]
Reveal mark scheme Mark scheme for question 3(a)(ii)
(a)(iii)

Give a reason why the three domain method of classification has been suggested.

[1]
Reveal mark scheme Mark scheme for question 3(a)(iii)
(b)

Figure 2 shows a cyanobacterium magnified 50 000 times.

The line AB shows the diameter of the bacterial cell.

Figure for question 3

(Source: © The Christian Science Monitor)

Figure 2

(b)(i)

Calculate the actual diameter of the cyanobacterium.

Give your answer in micrometres (µ m).

........ µm

[3]
Reveal mark scheme Mark scheme for question 3(b)(i)
(b)(ii)

Bacterial cells contain plasmids.

Describe three other features of a bacterial cell.

[3]
Reveal mark scheme Mark scheme for question 3(b)(ii)
(c)

Figure 3 shows a plasmid containing the human insulin gene.

Figure for question 3

Explain how the human insulin gene can be inserted into a plasmid.

[3]
Reveal mark scheme Mark scheme for question 3(c)

Paper 1: Biology 1 June 2019 Higher tier, Question 6 12 marks

(a)

Figure 8 shows the number of neurones in the brain of different animals.

Figure for question 6
(a)(i)

Calculate the difference between the number of neurones in the brain of the rat and the brain of the frog.

Give your answer in standard form.

........ neurones

[2]
Reveal mark scheme Mark scheme for question 6(a)(i)
(a)(ii)

Most neurones in the brain are unmyelinated whereas motor neurones are myelinated.

Explain why myelination is needed on motor neurones but not on neurones in the brain.

[3]
Reveal mark scheme Mark scheme for question 6(a)(ii)
(b)

Figure 9 shows a sensory neurone.

Figure for question 6
(b)(i)

Label the axon on Figure 9.

[1]
Reveal mark scheme Mark scheme for question 6(b)(i)
(b)(ii)

Describe the role of sensory neurones.

[2]
Reveal mark scheme Mark scheme for question 6(b)(ii)
(c)

Explain how impulses are transmitted at synapses.

[4]
Reveal mark scheme Mark scheme for question 6(c)

Paper 2: Biology 2 June 2018 Foundation tier, Question 5 12 marks

(a) Figure 9 shows a diagram of a red blood cell from a turtle and a diagram of a red blood cell from a human.

Figure for question 5
(a)
(a)(i)

These cells are animal cells.

Animal cells do not have

Question 5, shown as an image
[1]
Reveal mark scheme Mark scheme for question 5(a)(i)
(a)(ii)

The actual length of the red blood cell from a turtle is 20.5 μ m.

Calculate the length of the magnified image of the red blood cell of the turtle when magnified 400 ×.

........ μm

[2]
Reveal mark scheme Mark scheme for question 5(a)(ii)
(a)(iii)

The width of the human red blood cell, when magnified 400 ×, is 3.08 mm.

Calculate the actual width of the cell and show your answer in standard form.

........ mm

[2]
Reveal mark scheme Mark scheme for question 5(a)(iii)
(b)

Red blood cells are carried in veins and arteries.

Figure 10 shows the equipment used to measure the elasticity of an artery.

Figure for question 5
(b)(i)

Describe a method you could use to see how much the ring of tissue from an artery could stretch before it no longer returned to its original size.

[3]
Reveal mark scheme Mark scheme for question 5(b)(i)
(b)(ii)

Give one safety precaution you need to take when handling animal tissue such as blood vessels.

[1]
Reveal mark scheme Mark scheme for question 5(b)(ii)
(c)

Figure 11 shows the circulatory system of a frog.

Figure for question 5

Explain why the circulatory system of a frog is less efficient at carrying oxygen to the tissues than the circulatory system of a human.

[3]
Reveal mark scheme Mark scheme for question 5(c)

Paper 2: Biology 2 June 2018 Higher tier, Question 1 9 marks

(a) Figure 1 shows a diagram of a red blood cell from a turtle and a diagram of a red blood cell from a human.

Figure for question 1
(a)
(a)(i)

These cells are animal cells.

Animal cells do not have

Question 1, shown as an image
[1]
Reveal mark scheme Mark scheme for question 1(a)(i)
(a)(ii)

The actual length of the red blood cell from a turtle is 20.5 μ m.

Calculate the length of the magnified image of the red blood cell of the turtle when magnified 400 ×.

........ μm

[2]
Reveal mark scheme Mark scheme for question 1(a)(ii)
(a)(iii)

The width of the human red blood cell, when magnified 400 ×, is 3.08 mm.

Calculate the actual width of the cell and show your answer in standard form.

........ mm

[2]
Reveal mark scheme Mark scheme for question 1(a)(iii)
(b)

Red blood cells are carried in veins and arteries.

Figure 2 shows the equipment used to measure the elasticity of an artery.

Figure for question 1
(b)(i)

Describe a method you could use to see how much the ring of tissue from an artery could stretch before it no longer returned to its original size.

[3]
Reveal mark scheme Mark scheme for question 1(b)(i)
(b)(ii)

Give one safety precaution you need to take when handling animal tissue such as blood vessels.

[1]
Reveal mark scheme Mark scheme for question 1(b)(ii)

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